[PDF][PDF] BMP meets AML: induction of BMP signaling by a novel fusion gene promotes pediatric acute leukemia
JD Crispino, MM Le Beau - Cancer Cell, 2012 - cell.com
JD Crispino, MM Le Beau
Cancer Cell, 2012•cell.comIn this issue of Cancer Cell, Gruber et al. report that a significant proportion of children with
acute megakaryoblastic leukemia acquire a translocation that confers enhanced BMP
signaling and promotes self-renewal of hematopoietic progenitors. This study presents novel
therapeutic targets that may lead to improved therapies for this aggressive leukemia.
acute megakaryoblastic leukemia acquire a translocation that confers enhanced BMP
signaling and promotes self-renewal of hematopoietic progenitors. This study presents novel
therapeutic targets that may lead to improved therapies for this aggressive leukemia.
In this issue of Cancer Cell, Gruber et al. report that a significant proportion of children with acute megakaryoblastic leukemia acquire a translocation that confers enhanced BMP signaling and promotes self-renewal of hematopoietic progenitors. This study presents novel therapeutic targets that may lead to improved therapies for this aggressive leukemia.
cell.com