Mononuclear cell infiltration in glomeruli and renal interstitium is a prominent feature of
some types of glomerulonephritis, including lupus nephritis. The mechanism (s) underlying
monocyte influx into the kidney is not fully understood. Recently, monocyte chemoattractant
protein-1 (MCP-1) has been identified as a chemotactic factor involved in the recruitment of
monocytes/macrophages in the glomeruli of rats with mesangioproliferative as well as anti-
glomerular basement membrane glomerulonephritis. In the study presented here, renal …