Aminoglycosides are antibiotics commonly used to treat life-threatening Gram-negative
bacterial infections. However, their use is hampered by their severe nephrotoxicity due to
accumulation in renal proximal tubules. Several pathways have been implicated in the renal
uptake of aminoglycosides including megalin, an endocytic receptor in proximal tubular
cells. Here, we have used mouse models with genetic or functional megalin deficiency to
explore the contribution of megalin and other pathways to renal aminoglycoside uptake in …