Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure …
R Dagil, C O'shea, A Nykjær, AMJJ Bonvin… - Journal of Biological …, 2013 - jbc.org
Gentamicin is an aminoglycoside widely used in treatments of, in particular, enterococcal,
mycobacterial, and severe Gram-negative bacterial infections. Large doses of gentamicin
cause nephrotoxicity and ototoxicity, entering the cell via the receptor megalin. Until now, no
structural information has been available to describe the interaction with gentamicin in
atomic detail, and neither have any three-dimensional structures of domains from the human
megalin receptor been solved. To address this gap in our knowledge, we have solved the …
mycobacterial, and severe Gram-negative bacterial infections. Large doses of gentamicin
cause nephrotoxicity and ototoxicity, entering the cell via the receptor megalin. Until now, no
structural information has been available to describe the interaction with gentamicin in
atomic detail, and neither have any three-dimensional structures of domains from the human
megalin receptor been solved. To address this gap in our knowledge, we have solved the …
