Developmental programming of branching morphogenesis in the kidney
RV Sampogna, L Schneider… - Journal of the American …, 2015 - journals.lww.com
The kidney developmental program encodes the intricate branching and organization of
approximately 1 million functional units (nephrons). Branching regulation is poorly
understood, as is the source of a 10-fold variation in nephron number. Notably, low nephron
count increases the risk for developing hypertension and renal failure. To better understand
the source of this variation, we analyzed the complete gestational trajectory of mouse kidney
development. We constructed a computerized architectural map of the branching process …
approximately 1 million functional units (nephrons). Branching regulation is poorly
understood, as is the source of a 10-fold variation in nephron number. Notably, low nephron
count increases the risk for developing hypertension and renal failure. To better understand
the source of this variation, we analyzed the complete gestational trajectory of mouse kidney
development. We constructed a computerized architectural map of the branching process …