Maternal undernutrition during pregnancy alters the epigenetic landscape and the expression of endothelial function genes in male progeny
IN Zelko, J Zhu, J Roman - Nutrition research, 2019 - Elsevier
Recent studies point to the important role of in utero malnutrition in gene programming and
in the development of vascular diseases. We hypothesize that maternal undernutrition
affects vascular function in the offspring by promoting epigenetic changes that drive the
differential expression of genes involved in endothelial function. To test this, we exposed
mice to nutrient deprivation in utero and analyzed its effect on global DNA methylation and
expression of endothelium-specific genes in the pulmonary endothelium of the adult …
in the development of vascular diseases. We hypothesize that maternal undernutrition
affects vascular function in the offspring by promoting epigenetic changes that drive the
differential expression of genes involved in endothelial function. To test this, we exposed
mice to nutrient deprivation in utero and analyzed its effect on global DNA methylation and
expression of endothelium-specific genes in the pulmonary endothelium of the adult …