Gentamicin-induced acute kidney injury in an animal model involves programmed necrosis of the collecting duct
H Huang, WW Jin, M Huang, H Ji… - Journal of the …, 2020 - journals.lww.com
Background Gentamicin is a potent aminoglycoside antibiotic that targets gram-negative
bacteria, but nephrotoxicity limits its clinical application. The cause of gentamicin-induced
AKI has been attributed mainly to apoptosis of the proximal tubule cells. However, blocking
apoptosis only partially attenuates gentamicin-induced AKI in animals. Methods Mice treated
with gentamicin for 7 days developed AKI, and programmed cell death pathways were
examined using pharmacologic inhibitors and in RIPK3-deficient mice. Effects in porcine …
bacteria, but nephrotoxicity limits its clinical application. The cause of gentamicin-induced
AKI has been attributed mainly to apoptosis of the proximal tubule cells. However, blocking
apoptosis only partially attenuates gentamicin-induced AKI in animals. Methods Mice treated
with gentamicin for 7 days developed AKI, and programmed cell death pathways were
examined using pharmacologic inhibitors and in RIPK3-deficient mice. Effects in porcine …