[HTML][HTML] Absence of TMPRSS2: ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome
TMPRSS2: ERG gene fusions and PTEN deletions are the most common genomic
aberrations in prostate cancer. Recent work has suggested that the TMPRSS2: ERG fusion
is associated with a more aggressive phenotype. Similarly, PTEN deletion has been
associated with biochemical recurrence and lymph node metastasis. To date, there has
been no systematic analysis of the combined influence of genomic PTEN deletion with
TMPRSS2: ERG gene fusions on clinical parameters of prostate cancer progression. We …
aberrations in prostate cancer. Recent work has suggested that the TMPRSS2: ERG fusion
is associated with a more aggressive phenotype. Similarly, PTEN deletion has been
associated with biochemical recurrence and lymph node metastasis. To date, there has
been no systematic analysis of the combined influence of genomic PTEN deletion with
TMPRSS2: ERG gene fusions on clinical parameters of prostate cancer progression. We …
