TP53 missense mutation is associated with increased tumor-infiltrating T cells in primary prostate cancer

HB Kaur, J Lu, LB Guedes, L Maldonado, L Reitz… - Human pathology, 2019 - Elsevier
The makeup of the tumor immune microenvironment may be associated with tumor somatic
genomic alterations and plays a key role in tumor progression and response to
immunotherapy. We examined the association of tumor-infiltrating T-cell density with TP53
status in surgically treated primary prostate cancer using 3 independent tissue microarray
sets, including one set of tumors from grade-matched patients of European American or
African American ancestry (n= 391), a retrospective case-cohort of intermediate-and high …