[HTML][HTML] Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2*♦
P Giménez-Mascarell, I Oyenarte, S Hardy… - Journal of Biological …, 2017 - ASBMB
Phosphatases of regenerating liver (PRLs), the most oncogenic of all protein-tyrosine
phosphatases (PTPs), play a critical role in metastatic progression of cancers. Recent
findings established a new paradigm by uncovering that their association with magnesium
transporters of the cyclin M (CNNM) family causes a rise in intracellular magnesium levels
that promote oncogenic transformation. Recently, however, essential roles for regulation of
the circadian rhythm and reproduction of the CNNM family have been highlighted. Here, we …
phosphatases (PTPs), play a critical role in metastatic progression of cancers. Recent
findings established a new paradigm by uncovering that their association with magnesium
transporters of the cyclin M (CNNM) family causes a rise in intracellular magnesium levels
that promote oncogenic transformation. Recently, however, essential roles for regulation of
the circadian rhythm and reproduction of the CNNM family have been highlighted. Here, we …