The immune system protects our body against foreign pathogens. However, if it overshoots
or turns against itself, pro-inflammatory diseases, such as rheumatoid arthritis, inflammatory
bowel disease, or diabetes develop. Ions, the most basic signaling molecules, shape
intracellular signaling cascades resulting in immune cell activation and subsequent immune
responses. Mutations in ion channels required for calcium signaling result in human
immunodeficiencies and highlight those ion channels as valued targets for therapies against …