Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic …
Although the pancreatic duodenal homeobox 1 (Pdx-1) transcription factor is known to play
an indispensable role in β cell development and secretory function, recent data also
implicate Pdx-1 in the maintenance of endoplasmic reticulum (ER) health. The sarco-
endoplasmic reticulum Ca 2+ ATPase 2b (SERCA2b) pump maintains a steep Ca 2+
gradient between the cytosol and ER lumen. In models of diabetes, our data demonstrated
loss of β cell Pdx-1 that occurs in parallel with altered SERCA2b expression, whereas in …
an indispensable role in β cell development and secretory function, recent data also
implicate Pdx-1 in the maintenance of endoplasmic reticulum (ER) health. The sarco-
endoplasmic reticulum Ca 2+ ATPase 2b (SERCA2b) pump maintains a steep Ca 2+
gradient between the cytosol and ER lumen. In models of diabetes, our data demonstrated
loss of β cell Pdx-1 that occurs in parallel with altered SERCA2b expression, whereas in …
