TRPM7 is involved in angiotensin II induced cardiac fibrosis development by mediating calcium and magnesium influx
Y Yu, S Chen, C Xiao, Y Jia, J Guo, J Jiang, P Liu - Cell Calcium, 2014 - Elsevier
Cardiac fibrosis is involved in a lot of cardiovascular pathological processes. Cardiac
fibrosis can block conduction, cause hypoxia, strengthen myocardial stiffness, create
electrical heterogeneity, and hamper systolic ejection, which is associated with the
development of arrhythmia, heart failure and sudden cardiac death. Besides the initial
stimulating factors, the cardiac fibroblasts (CFs) are the principal responsible cells in the
fibrogenesis cascade of events. TRPM7, a member of the TRPM (Melastatin) subfamily, is a …
fibrosis can block conduction, cause hypoxia, strengthen myocardial stiffness, create
electrical heterogeneity, and hamper systolic ejection, which is associated with the
development of arrhythmia, heart failure and sudden cardiac death. Besides the initial
stimulating factors, the cardiac fibroblasts (CFs) are the principal responsible cells in the
fibrogenesis cascade of events. TRPM7, a member of the TRPM (Melastatin) subfamily, is a …