[HTML][HTML] MIP-1α utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells
Y Oba, JW Lee, LA Ehrlich, HY Chung, DF Jelinek… - Experimental …, 2005 - Elsevier
OBJECTIVES: Macrophage inflammatory protein-1α (MIP-1α), an osteoclast (OCL)
stimulatory factor produced by primary multiple myeloma (MM) cells, increases bone
destruction and tumor burden in murine models of MM. Several chemokine receptors
(CCR1, CCR5, and CCR9) mediate the effects of MIP-1α. In this study, we determined which
of these mediates the effects of MIP-1α on human OCL formation and myeloma cells.
METHODS: We employed RT-PCR analysis, neutralizing antibodies to CCR1 and CCR5 as …
stimulatory factor produced by primary multiple myeloma (MM) cells, increases bone
destruction and tumor burden in murine models of MM. Several chemokine receptors
(CCR1, CCR5, and CCR9) mediate the effects of MIP-1α. In this study, we determined which
of these mediates the effects of MIP-1α on human OCL formation and myeloma cells.
METHODS: We employed RT-PCR analysis, neutralizing antibodies to CCR1 and CCR5 as …