[HTML][HTML] RANTES and MIP-1α activate stats in T cells
M Wong, EN Fish - Journal of Biological Chemistry, 1998 - ASBMB
The chemokines RANTES (regulated on activation, normal T cell expressed and secreted)
and MIP (macrophage inflammatory protein)-1α have been implicated in regulating T cell
functions. RANTES-induced T cell activation is apparently mediated via two distinct signal
transduction cascades: one linked to recruitment of pertussis toxin-sensitive G proteins and
the other linked to protein-tyrosine kinase activation. In this report, we identified that the
transcription factors Stat1 and Stat3 (for signal transducers and activators of transcription) …
and MIP (macrophage inflammatory protein)-1α have been implicated in regulating T cell
functions. RANTES-induced T cell activation is apparently mediated via two distinct signal
transduction cascades: one linked to recruitment of pertussis toxin-sensitive G proteins and
the other linked to protein-tyrosine kinase activation. In this report, we identified that the
transcription factors Stat1 and Stat3 (for signal transducers and activators of transcription) …