Chemokines are chemotactic cytokines, and interleukin (IL)-8 represents the prototypical
chemokine. As the name chemokine indicates, IL-8 is responsible for inducing chemotaxis,
which is the directed migration of cells to a site of inflammation. Chemokines are divided into
broad categories based on their protein structure. CXC chemokines possess cysteine
residues with an intervening amino acid. There are four cysteines, resulting in two disulfide
bonds. The CC chemokines do not have the intervening amino acid between the cysteines …