The involvement of macrophages (MΦs) in Th17‐cell responses is still poorly understood. While neutrophils are thought to be the predominant effector of Th17‐cell responses, IL‐17 is also known to induce myelotropic chemokines and growth factors. Other T‐cell‐derived cytokines induce non‐classical functions, suggesting that IL‐17 sigxnaling may similarly elicit unique MΦ functions. Here, we characterized the expression of subunits of the IL‐17 receptor on primary murine MΦs from different anatomical compartments. The greatest expression of IL‐17 receptors was observed on mucosal Ly6C^hi "inflammatory" MΦs. We further observed upregulation of IL‐17 receptors in vitro on bone marrow‐derived macrophages (BMMΦs) in response to peptidoglycan or CpG oligonucleotide stimuli, and in vivo, upon CFA administration. Macrophages expressing IL‐17 receptors were observed infiltrating the hearts of mice with myocarditis, and genetic ablation of IL‐17RA altered MΦ recruitment. Treating primary MΦs from a wide variety of different anatomic sources (as well as cell lines) with IL‐17A induced the production of unique profiles of cytokines and chemokines, including GM‐CSF, IL‐3, IL‐9, CCL4/MIP‐1β and CCL5/RANTES. IL‐17A also induced production of IL‐12p70; IL‐17‐signaling‐deficient MΦs elicited diminished IFN‐γ production by responding DO11.10 CD4⁺ T cells when used as APCs. These data indicate that MΦs from different anatomic locations direct IL‐17‐mediated responses.