Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis
S Mashiko, S Bouguermouh, M Rubio, N Baba… - Journal of Allergy and …, 2015 - Elsevier
Background Psoriasis is a systemic inflammatory disease in which IL-17 and IL-22 levels are
markedly increased in the skin and blood. The prevalent concept, using skin cells that are
isolated from psoriatic plaques and examined after cell expansion and in vitro stimulation, is
that IL-17 and IL-22 production essentially results from T cells and the rare type 3 innate
lymphoid cells. Objective We sought to examine the cellular source of IL-17A and IL-22 at
the protein and transcriptional single-cell level immediately after ex vivo skin cell isolation …
markedly increased in the skin and blood. The prevalent concept, using skin cells that are
isolated from psoriatic plaques and examined after cell expansion and in vitro stimulation, is
that IL-17 and IL-22 production essentially results from T cells and the rare type 3 innate
lymphoid cells. Objective We sought to examine the cellular source of IL-17A and IL-22 at
the protein and transcriptional single-cell level immediately after ex vivo skin cell isolation …