[HTML][HTML] Immune-mediated inflammatory disease therapeutics: past, present and future

IB McInnes, EM Gravallese - Nature Reviews Immunology, 2021 - nature.com
IB McInnes, EM Gravallese
Nature Reviews Immunology, 2021nature.com
Immune-mediated inflammatory diseases are common and clinically diverse. Although they
are currently incurable, the therapeutic armamentarium for immune-mediated inflammatory
diseases has been transformed in the past two decades. We have moved from the wide
application of broad-spectrum immune modulators to the routine use of agents with exquisite
specificity, arising from monoclonal and molecular biotechnology and more recently from
highly targeted medicinal chemistry. Here we describe key advances and lessons that drove …
Abstract
Immune-mediated inflammatory diseases are common and clinically diverse. Although they are currently incurable, the therapeutic armamentarium for immune-mediated inflammatory diseases has been transformed in the past two decades. We have moved from the wide application of broad-spectrum immune modulators to the routine use of agents with exquisite specificity, arising from monoclonal and molecular biotechnology and more recently from highly targeted medicinal chemistry. Here we describe key advances and lessons that drove this remarkable progress and thereafter reflect on the next steps in this ongoing journey.
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