[HTML][HTML] Peroxisome proliferator-activated receptor α deficiency abolishes the response of lipogenic gene expression to re-feeding: restoration of the normal response …

AM Hebbachi, BL Knight, D Wiggins, DD Patel… - Journal of biological …, 2008 - ASBMB
The mRNA expression of lipogenic genes Scd-1 and Fas is regulated partly by the insulin-
sensitive transcription factor SREBP-1c and liver X receptor α (LXRα). Compared with
normal mice, the increase in the mRNA expression of hepatic Scd-1, Fas, and Srebp-1c was
severely attenuated in peroxisome proliferator-activated receptor α (PPARα)-deficient mice
during the transition from the starved to the re-fed states. The concentration of the membrane-
bound form of SREBP-1c was also lower in the livers of the PPARα-deficient mice during re …