[HTML][HTML] SCD1 activity in muscle increases triglyceride PUFA content, exercise capacity, and PPARΔ expression in mice [S]
MP Rogowski, MT Flowers, AD Stamatikos… - Journal of lipid …, 2013 - ASBMB
Stearoyl-CoA desaturase (SCD) 1 converts saturated fatty acids into monounsaturated fatty
acids. Using muscle overexpression, we sought to determine the role of SCD1 expression in
glucose and lipid metabolism and its effects on exercise capacity in mice. Wild-type C57Bl/6
(WT) and SCD1 muscle transgenic (SCD1-Tg) mice were generated, and expression of the
SCD1 transgene was restricted to skeletal muscle. SCD1 overexpression was associated
with increased triglyceride (TG) content. The fatty acid composition of the muscle revealed a …
acids. Using muscle overexpression, we sought to determine the role of SCD1 expression in
glucose and lipid metabolism and its effects on exercise capacity in mice. Wild-type C57Bl/6
(WT) and SCD1 muscle transgenic (SCD1-Tg) mice were generated, and expression of the
SCD1 transgene was restricted to skeletal muscle. SCD1 overexpression was associated
with increased triglyceride (TG) content. The fatty acid composition of the muscle revealed a …