[HTML][HTML] Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease
M Pawlak, P Lefebvre, B Staels - Journal of hepatology, 2015 - Elsevier
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor
subfamily. Many PPARα target genes are involved in fatty acid metabolism in tissues with
high oxidative rates such as muscle, heart and liver. PPARα activation, in combination with
PPARβ/δ agonism, improves steatosis, inflammation and fibrosis in pre-clinical models of
non-alcoholic fatty liver disease, identifying a new potential therapeutic area. In this review …
factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor
subfamily. Many PPARα target genes are involved in fatty acid metabolism in tissues with
high oxidative rates such as muscle, heart and liver. PPARα activation, in combination with
PPARβ/δ agonism, improves steatosis, inflammation and fibrosis in pre-clinical models of
non-alcoholic fatty liver disease, identifying a new potential therapeutic area. In this review …