[HTML][HTML] A probabilistic approach to histologic diagnosis of antibody-mediated rejection in kidney transplant biopsies
PF Halloran, KS Famulski, J Chang - American Journal of Transplantation, 2017 - Elsevier
Histologic diagnosis of antibody-mediated rejection (ABMR) in kidney transplant biopsies
uses lesion score cutoffs such as 0 versus> 0 rather than actual scores and requires donor-
specific antibody (DSA); however, cutoffs lose information, and DSA is not always reliable.
Using microarray-derived molecular ABMR scores as a histology-independent estimate of
ABMR in 703 biopsies, we reassessed criteria for ABMR to determine relative importance of
various lesions, the utility of equations using actual scores rather than cutoffs, and the …
uses lesion score cutoffs such as 0 versus> 0 rather than actual scores and requires donor-
specific antibody (DSA); however, cutoffs lose information, and DSA is not always reliable.
Using microarray-derived molecular ABMR scores as a histology-independent estimate of
ABMR in 703 biopsies, we reassessed criteria for ABMR to determine relative importance of
various lesions, the utility of equations using actual scores rather than cutoffs, and the …