[HTML][HTML] Low density lipoprotein receptor-related protein 1 (LRP1) forms a signaling complex with platelet-derived growth factor receptor-β in endosomes and …
SC Muratoglu, I Mikhailenko, C Newton… - Journal of Biological …, 2010 - ASBMB
In addition to its endocytic function, the low density lipoprotein receptor-related protein 1
(LRP1) also contributes to cell signaling events. In the current study, the potential of LRP1 to
modulate the platelet-derived growth factor (PDGF) signaling pathway was investigated.
PDGF is a key regulator of cell migration and proliferation and mediates the tyrosine
phosphorylation of LRP1 within its cytoplasmic domain. In WI-38 fibroblasts, PDGF-mediated
LRP1 tyrosine phosphorylation occurred at 37° C but not at 4° C, where endocytosis is …
(LRP1) also contributes to cell signaling events. In the current study, the potential of LRP1 to
modulate the platelet-derived growth factor (PDGF) signaling pathway was investigated.
PDGF is a key regulator of cell migration and proliferation and mediates the tyrosine
phosphorylation of LRP1 within its cytoplasmic domain. In WI-38 fibroblasts, PDGF-mediated
LRP1 tyrosine phosphorylation occurred at 37° C but not at 4° C, where endocytosis is …