Mechanisms of cellular uptake of thrombin-antithrombin II complexes role of the low-density lipoprotein receptor-related protein as a serpin-enzyme complex receptor
DK Strickland, MZ Kounnas - Trends in cardiovascular medicine, 1997 - Elsevier
Serine proteinase inhibitors (serpins) such as antithrombin III inhibit target proteinases by
forming a stable complexwith the enzyme. Once formed, several serpin-enzyme complexes
(SECs) are removed from the circulation by a receptor, termed the SEC receptor, that is
present in the liver. Until recently, the identity of this clearance receptor remained unknown;
however, data are now available that strongly implicates one member of the low-density
lipoprotein (LDL) receptor family as a candidate for the SEC receptor. This receptor, known …
forming a stable complexwith the enzyme. Once formed, several serpin-enzyme complexes
(SECs) are removed from the circulation by a receptor, termed the SEC receptor, that is
present in the liver. Until recently, the identity of this clearance receptor remained unknown;
however, data are now available that strongly implicates one member of the low-density
lipoprotein (LDL) receptor family as a candidate for the SEC receptor. This receptor, known …