[HTML][HTML] Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity
RL Jacobs, Y Zhao, DPY Koonen, T Sletten… - Journal of Biological …, 2010 - ASBMB
Phosphatidylcholine (PC) is synthesized from choline via the CDP-choline pathway. Liver
cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine,
catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). The current study
investigates whether or not hepatic PC biosynthesis is linked to diet-induced obesity.
Pemt+/+ mice fed a high fat diet for 10 weeks increased in body mass by 60% and displayed
insulin resistance, whereas Pemt−/− mice did not. Compared with Pemt+/+ mice, Pemt …
cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine,
catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). The current study
investigates whether or not hepatic PC biosynthesis is linked to diet-induced obesity.
Pemt+/+ mice fed a high fat diet for 10 weeks increased in body mass by 60% and displayed
insulin resistance, whereas Pemt−/− mice did not. Compared with Pemt+/+ mice, Pemt …