The role of GIP in α-cells and glucagon secretion
K El, JE Campbell - Peptides, 2020 - Elsevier
Glucose-dependent insulinotropic polypeptide (GIP) is an intestinally derived peptide that is
secreted in response to feeding. The GIP receptor (GIPR) is expressed in many cell types
involved in the regulation of metabolism, including α-and β-cells. Glucagon and insulin exert
tremendous control over glucose metabolism. Thus, GIP action in islets strongly dictates
metabolic control in the postprandial state. Loss of GIPR activity in β-cells is a characteristic
of type 2 diabetes (T2D) which associates with reduced postprandial insulin secretion and …
secreted in response to feeding. The GIP receptor (GIPR) is expressed in many cell types
involved in the regulation of metabolism, including α-and β-cells. Glucagon and insulin exert
tremendous control over glucose metabolism. Thus, GIP action in islets strongly dictates
metabolic control in the postprandial state. Loss of GIPR activity in β-cells is a characteristic
of type 2 diabetes (T2D) which associates with reduced postprandial insulin secretion and …