Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway
D Kondrikov, A Elmansi, RT Bragg, T Mobley… - Experimental …, 2020 - Elsevier
Osteoporosis is an age-related deterioration in bone health that is, at least in part, a stem
cell disease. The different mechanisms and signaling pathways that change with age and
contribute to the development of osteoporosis are being identified. One key upstream
mechanism that appears to target a number of osteogenic pathways with age is kynurenine,
a tryptophan metabolite and an endogenous Aryl hydrocarbon receptor (AhR) agonist. The
AhR signaling pathway has been reported to promote aging phenotypes across species and …
cell disease. The different mechanisms and signaling pathways that change with age and
contribute to the development of osteoporosis are being identified. One key upstream
mechanism that appears to target a number of osteogenic pathways with age is kynurenine,
a tryptophan metabolite and an endogenous Aryl hydrocarbon receptor (AhR) agonist. The
AhR signaling pathway has been reported to promote aging phenotypes across species and …