[HTML][HTML] Y box-binding protein-1 binds to the dengue virus 3′-untranslated region and mediates antiviral effects
SM Paranjape, E Harris - Journal of Biological Chemistry, 2007 - ASBMB
Dengue virus, a member of the family Flaviviridae, poses a serious public health threat
worldwide. Dengue virus is a positive-sense RNA virus that harbors a genome of∼ 10.7 kb.
Replication of dengue virus is mediated coordinately by cis-acting genomic sequences, viral
proteins, and host cell factors. We have isolated and identified several host cell factors from
baby hamster kidney cell extracts that bind with high specificity and high affinity to
sequences within the untranslated regions of the dengue virus genome. Among the factors …
worldwide. Dengue virus is a positive-sense RNA virus that harbors a genome of∼ 10.7 kb.
Replication of dengue virus is mediated coordinately by cis-acting genomic sequences, viral
proteins, and host cell factors. We have isolated and identified several host cell factors from
baby hamster kidney cell extracts that bind with high specificity and high affinity to
sequences within the untranslated regions of the dengue virus genome. Among the factors …