Sex-related differences in circadian-dependent tolerance of Irinotecan (I) added to chronomodulated (chrono) 5-Fluorouracil (F), Leucovorin (L) and Oxaliplatin (O) …
F Levi, C Garufi, A Karaboué, C Focan… - Annals of …, 2017 - annalsofoncology.org
Background: The least toxic time (LTT) of I varied by up to 8 hours according to sex in mice
(Li et al. Cancer Res 2013). The translational relevance was investigated through a post-hoc
analysis of a randomised trial, where the planned methodology did not identify the LTT of I
combined with F, L and O (chronoIFLO) in the whole population. Methods: 199 MCC patients
at 18 EU centers were randomised to receive chrono I (180 mg/m2 over 6-h, with peak
delivery at 1: 00, 5: 00, 9: 00, 13: 00, 17: 00 or 21: 00) on day (d) 1, followed by fixed-time …
(Li et al. Cancer Res 2013). The translational relevance was investigated through a post-hoc
analysis of a randomised trial, where the planned methodology did not identify the LTT of I
combined with F, L and O (chronoIFLO) in the whole population. Methods: 199 MCC patients
at 18 EU centers were randomised to receive chrono I (180 mg/m2 over 6-h, with peak
delivery at 1: 00, 5: 00, 9: 00, 13: 00, 17: 00 or 21: 00) on day (d) 1, followed by fixed-time …
