Circadian timing in cancer treatments
F Lévi, A Okyar, S Dulong, PF Innominato… - Annual review of …, 2010 - annualreviews.org
The circadian timing system is composed of molecular clocks, which drive 24-h changes in
xenobiotic metabolism and detoxification, cell cycle events, DNA repair, apoptosis, and
angiogenesis. The cellular circadian clocks are coordinated by endogenous physiological
rhythms, so that they tick in synchrony in the host tissues that can be damaged by anticancer
agents. As a result, circadian timing can modify 2-to 10-fold the tolerability of anticancer
medications in experimental models and in cancer patients. Improved efficacy is also seen …
xenobiotic metabolism and detoxification, cell cycle events, DNA repair, apoptosis, and
angiogenesis. The cellular circadian clocks are coordinated by endogenous physiological
rhythms, so that they tick in synchrony in the host tissues that can be damaged by anticancer
agents. As a result, circadian timing can modify 2-to 10-fold the tolerability of anticancer
medications in experimental models and in cancer patients. Improved efficacy is also seen …
