Transmission Electron Microscopic Study of Antibiotic Action on Klebsiella pneumoniae Biofilm
J Zahller, PS Stewart - Antimicrobial agents and chemotherapy, 2002 - Am Soc Microbiol
J Zahller, PS Stewart
Antimicrobial agents and chemotherapy, 2002•Am Soc MicrobiolThe penetration of ampicillin and ciprofloxacin through biofilms formed by Klebsiella
pneumoniae was confirmed by transmission electron microscopic observation of antibiotic-
affected cells at the distal edge of the biofilm. Because the bacteria nevertheless survived
antibiotic treatment, some protective mechanism other than inadequate penetration must
have been at work in the biofilm.
pneumoniae was confirmed by transmission electron microscopic observation of antibiotic-
affected cells at the distal edge of the biofilm. Because the bacteria nevertheless survived
antibiotic treatment, some protective mechanism other than inadequate penetration must
have been at work in the biofilm.
Abstract
The penetration of ampicillin and ciprofloxacin through biofilms formed by Klebsiella pneumoniae was confirmed by transmission electron microscopic observation of antibiotic-affected cells at the distal edge of the biofilm. Because the bacteria nevertheless survived antibiotic treatment, some protective mechanism other than inadequate penetration must have been at work in the biofilm.
American Society for Microbiology