[HTML][HTML] Human Urinary Composition Controls Antibacterial Activity of Siderocalin*♦
RR Shields-Cutler, JR Crowley, CS Hung… - Journal of Biological …, 2015 - ASBMB
During Escherichia coli urinary tract infections, cells in the human urinary tract release the
antimicrobial protein siderocalin (SCN; also known as lipocalin 2, neutrophil gelatinase-
associated lipocalin/NGAL, or 24p3). SCN can interfere with E. coli iron acquisition by
sequestering ferric iron complexes with enterobactin, the conserved E. coli siderophore.
Here, we find that human urinary constituents can reverse this relationship, instead making
enterobactin critical for overcoming SCN-mediated growth restriction. Urinary control of SCN …
antimicrobial protein siderocalin (SCN; also known as lipocalin 2, neutrophil gelatinase-
associated lipocalin/NGAL, or 24p3). SCN can interfere with E. coli iron acquisition by
sequestering ferric iron complexes with enterobactin, the conserved E. coli siderophore.
Here, we find that human urinary constituents can reverse this relationship, instead making
enterobactin critical for overcoming SCN-mediated growth restriction. Urinary control of SCN …