[HTML][HTML] Structural variation governs substrate specificity for organic anion transporter (OAT) homologs: potential remote sensing by OAT family members
G Kaler, DM Truong, A Khandelwal, M Nagle… - Journal of Biological …, 2007 - ASBMB
Organic anion transporters (OATs, SLC22) interact with a remarkably diverse array of
endogenous and exogenous organic anions. However, little is known about the structural
features that determine their substrate selectivity. We examined the substrate binding
preferences and transport function of olfactory organic anion transporter, Oat6, in
comparison with the more broadly expressed transporter, Oat1 (first identified as NKT). In
analyzing interactions of both transporters with over 40 structurally diverse organic anions …
endogenous and exogenous organic anions. However, little is known about the structural
features that determine their substrate selectivity. We examined the substrate binding
preferences and transport function of olfactory organic anion transporter, Oat6, in
comparison with the more broadly expressed transporter, Oat1 (first identified as NKT). In
analyzing interactions of both transporters with over 40 structurally diverse organic anions …
