RNA-Seq quantification of hepatic drug processing genes in germ-free mice
FP Selwyn, JY Cui, CD Klaassen - Drug metabolism and disposition, 2015 - Elsevier
Intestinal bacteria have been shown to be important in regulating host intermediary
metabolism and contributing to obesity. However, relatively less is known about the effect of
intestinal bacteria on the expression of hepatic drug-processing genes in the host. This
study characterizes the expression of hepatic drug-processing genes in germ-free (GF) mice
using RNA-Seq. Total RNA were isolated from the livers of adult male conventional and GF
C57BL/6J mice (n= 3 per group). In the livers of GF mice, the mRNA of the aryl hydrocarbon …
metabolism and contributing to obesity. However, relatively less is known about the effect of
intestinal bacteria on the expression of hepatic drug-processing genes in the host. This
study characterizes the expression of hepatic drug-processing genes in germ-free (GF) mice
using RNA-Seq. Total RNA were isolated from the livers of adult male conventional and GF
C57BL/6J mice (n= 3 per group). In the livers of GF mice, the mRNA of the aryl hydrocarbon …
