[HTML][HTML] Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning
The multispecific organic anion transporters, OAT1 (SLC22A6) and OAT3 (SLC22A8), the
main kidney elimination pathways for many common drugs, are often considered to have
largely-redundant roles. However, whereas examination of metabolomics data from Oat-
knockout mice (Oat1 and Oat3KO) revealed considerable overlap, over a hundred
metabolites were increased in the plasma of one or the other of these knockout mice. Many
of these relatively unique metabolites are components of distinct biochemical and signaling …
main kidney elimination pathways for many common drugs, are often considered to have
largely-redundant roles. However, whereas examination of metabolomics data from Oat-
knockout mice (Oat1 and Oat3KO) revealed considerable overlap, over a hundred
metabolites were increased in the plasma of one or the other of these knockout mice. Many
of these relatively unique metabolites are components of distinct biochemical and signaling …