Evidence for the validity of pyridoxic acid (PDA) as a plasma-based endogenous probe for OAT1 and OAT3 function in healthy subjects
H Shen, VK Holenarsipur, TT Mariappan… - The Journal of …, 2019 - Elsevier
Plasma pyridoxic acid (PDA) and homovanillic acid (HVA) were recently identified as novel
endogenous biomarkers of organic anion transporter (OAT) 1/3 function in monkeys.
Consequently, this clinical study assessed the dynamic changes and utility of plasma PDA
and HVA as an initial evaluation of OAT1/3 inhibition in early-phase drug development. The
study was designed as a single-dose randomized, three-phase, crossover study; 14 Indian
healthy volunteers received probenecid (PROB)(1000 mg orally) alone, furosemide …
endogenous biomarkers of organic anion transporter (OAT) 1/3 function in monkeys.
Consequently, this clinical study assessed the dynamic changes and utility of plasma PDA
and HVA as an initial evaluation of OAT1/3 inhibition in early-phase drug development. The
study was designed as a single-dose randomized, three-phase, crossover study; 14 Indian
healthy volunteers received probenecid (PROB)(1000 mg orally) alone, furosemide …
