There has been a recent interest in the broader physiological importance of multispecific"
drug" transporters of the SLC and ABC transporter families. Here, a novel multi-tiered
systems biology approach was used to predict metabolites and signaling molecules
potentially affected by the in vivo deletion of organic anion transporter 1 (Oat1, Slc22a6,
originally NKT), a major kidney-expressed drug transporter. Validation of some predictions
in wet-lab assays, together with re-evaluation of existing transport and knock-out …