Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice
SA Eraly, V Vallon, DA Vaughn, JA Gangoiti… - Journal of Biological …, 2006 - jbc.org
The" classical" organic anion secretory pathway of the renal proximal tubule is critical for the
renal excretion of the prototypic organic anion, para-aminohippurate, as well as of a large
number of commonly prescribed drugs among other significant substrates. Organic anion
transporter 1 (OAT1), originally identified as NKT (Lopez-Nieto, CE, You, G., Bush, KT,
Barros, EJG, Beier, DR, and Nigam, SK (1997) J. Biol. Chem. 272, 6471–6478), has
physiological properties consistent with a role in this pathway. However, several other …
renal excretion of the prototypic organic anion, para-aminohippurate, as well as of a large
number of commonly prescribed drugs among other significant substrates. Organic anion
transporter 1 (OAT1), originally identified as NKT (Lopez-Nieto, CE, You, G., Bush, KT,
Barros, EJG, Beier, DR, and Nigam, SK (1997) J. Biol. Chem. 272, 6471–6478), has
physiological properties consistent with a role in this pathway. However, several other …
