Drugs interacting with organic anion transporter-1 affect uptake of Tc-99m-mercaptoacetyl-triglycine (MAG3) in the human kidney: therapeutic drug interaction in Tc …
N Takahara, T Saga, M Inubushi, H Kusuhara… - Nuclear Medicine and …, 2013 - Elsevier
INTRODUCTION: Renal uptake of Tc-99m-MG3 involves organic anion transporter (OAT).
Treatment with drugs showing OAT affinity might interfere with renal uptake of Tc-99m-
MAG3, leading to misinterpretation in Tc-99m-MAG3. This study was conducted to discuss a
possible drug interference with Tc-99m-MAG3 diagnosis on OAT sites. METHODS: Renal
uptake and plasma clearance of Tc-99m-MAG3 were analyzed in healthy volunteers under
control and OAT1 and OAT3 related drug treatment conditions. An in vitro uptake study using …
Treatment with drugs showing OAT affinity might interfere with renal uptake of Tc-99m-
MAG3, leading to misinterpretation in Tc-99m-MAG3. This study was conducted to discuss a
possible drug interference with Tc-99m-MAG3 diagnosis on OAT sites. METHODS: Renal
uptake and plasma clearance of Tc-99m-MAG3 were analyzed in healthy volunteers under
control and OAT1 and OAT3 related drug treatment conditions. An in vitro uptake study using …
