OAT, OATP, and MRP drug transporters and the remote sensing and signaling theory
SK Nigam, JC Granados - Annual review of pharmacology and …, 2023 - annualreviews.org
The coordinated movement of organic anions (eg, drugs, metabolites, signaling molecules,
nutrients, antioxidants, gut microbiome products) between tissues and body fluids depends,
in large part, on organic anion transporters (OATs)[solute carrier 22 (SLC22)], organic anion
transporting polypeptides (OATPs)[solute carrier organic (SLCO)], and multidrug resistance
proteins (MRPs)[ATP-binding cassette, subfamily C (ABCC)]. Depending on the range of
substrates, transporters in these families can be considered multispecific, oligospecific, or …
nutrients, antioxidants, gut microbiome products) between tissues and body fluids depends,
in large part, on organic anion transporters (OATs)[solute carrier 22 (SLC22)], organic anion
transporting polypeptides (OATPs)[solute carrier organic (SLCO)], and multidrug resistance
proteins (MRPs)[ATP-binding cassette, subfamily C (ABCC)]. Depending on the range of
substrates, transporters in these families can be considered multispecific, oligospecific, or …
