Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis
SY Ahn, SK Nigam - Molecular pharmacology, 2009 - Elsevier
Organic anion transporters (Oats) are located in the barrier epithelia of diverse organs,
where they mediate the absorption and excretion of a wide range of metabolites, signaling
molecules, and xenobiotics. Although their interactions with a broad group of substrates
have been extensively studied and described, the primary physiological role of Oats remains
elusive. The presence of overlapping substrate specificities among the different Oat
isoforms, together with recent metabolomic data from the Oat1, Oat3, and renal-specific …
where they mediate the absorption and excretion of a wide range of metabolites, signaling
molecules, and xenobiotics. Although their interactions with a broad group of substrates
have been extensively studied and described, the primary physiological role of Oats remains
elusive. The presence of overlapping substrate specificities among the different Oat
isoforms, together with recent metabolomic data from the Oat1, Oat3, and renal-specific …
