Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3
How organs sense circulating metabolites is a key question. Here, we show that the
multispecific organic anion transporters of drugs, OAT1 (SLC22A6 or NKT) and OAT3
(SLC22A8), play a role in organ sensing. Metabolomics analyses of the serum of Oat1 and
Oat3 knockout mice revealed changes in tryptophan derivatives involved in metabolism and
signaling. Several of these metabolites are derived from the gut microbiome and are
implicated as uremic toxins in chronic kidney disease. Direct interaction with the transporters …
multispecific organic anion transporters of drugs, OAT1 (SLC22A6 or NKT) and OAT3
(SLC22A8), play a role in organ sensing. Metabolomics analyses of the serum of Oat1 and
Oat3 knockout mice revealed changes in tryptophan derivatives involved in metabolism and
signaling. Several of these metabolites are derived from the gut microbiome and are
implicated as uremic toxins in chronic kidney disease. Direct interaction with the transporters …
