Mechanisms of renal fibrosis
BD Humphreys - Annual review of physiology, 2018 - annualreviews.org
Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging
and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half
of adults above age 70 and 10% of the world's population. Although no targeted therapy yet
exists to slow renal fibrosis, a number of important recent advances have clarified the
cellular and molecular mechanisms underlying the disease. In this review, I highlight these
advances with a focus on cells and pathways that may be amenable to therapeutic targeting …
and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half
of adults above age 70 and 10% of the world's population. Although no targeted therapy yet
exists to slow renal fibrosis, a number of important recent advances have clarified the
cellular and molecular mechanisms underlying the disease. In this review, I highlight these
advances with a focus on cells and pathways that may be amenable to therapeutic targeting …
