Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis
S Hao, W He, Y Li, H Ding, Y Hou, J Nie… - Journal of the …, 2011 - journals.lww.com
Because fibrotic kidneys exhibit aberrant activation of β-catenin signaling, this pathway may
be a potential target for antifibrotic therapy. In this study, we examined the effects of β-
catenin activation on tubular epithelial-mesenchymal transition (EMT) in vitro and evaluated
the therapeutic efficacy of the peptidomimetic small molecule ICG-001, which specifically
disrupts β-catenin-mediated gene transcription, in obstructive nephropathy. In vitro, ectopic
expression of stabilized β-catenin in tubular epithelial (HKC-8) cells suppressed E-cadherin …
be a potential target for antifibrotic therapy. In this study, we examined the effects of β-
catenin activation on tubular epithelial-mesenchymal transition (EMT) in vitro and evaluated
the therapeutic efficacy of the peptidomimetic small molecule ICG-001, which specifically
disrupts β-catenin-mediated gene transcription, in obstructive nephropathy. In vitro, ectopic
expression of stabilized β-catenin in tubular epithelial (HKC-8) cells suppressed E-cadherin …