Genetic factors are critical in multiple sclerosis (MS), and it is conceivable that the pattern
recognition receptors of the innate immune system are of pathogenic importance. We
therefore developed two novel assays capable of analyzing 42 single-nucleotide
polymorphisms in the human genes encoding TLR1-10, NOD1-2, DDX58, and IFIH1. Using
these assays, we genotyped 963 MS patients and 960 controls, and analyzed for possible
associations to MS diagnosis, clinical course, severity, and age at onset. Our results support …