Environmental risk factors for type 1 diabetes
M Rewers, J Ludvigsson - The Lancet, 2016 - thelancet.com
The Lancet, 2016•thelancet.com
The incidence of type 1 diabetes has risen considerably in the past 30 years due to changes
in the environment that have been only partially identified. In this Series paper, we critically
discuss candidate triggers of islet autoimmunity and factors thought to promote progression
from autoimmunity to overt type 1 diabetes. We revisit previously proposed hypotheses to
explain the growth in the incidence of type 1 diabetes in light of current data. Finally, we
suggest a unified model in which immune tolerance to β cells can be broken by several …
in the environment that have been only partially identified. In this Series paper, we critically
discuss candidate triggers of islet autoimmunity and factors thought to promote progression
from autoimmunity to overt type 1 diabetes. We revisit previously proposed hypotheses to
explain the growth in the incidence of type 1 diabetes in light of current data. Finally, we
suggest a unified model in which immune tolerance to β cells can be broken by several …
Summary
The incidence of type 1 diabetes has risen considerably in the past 30 years due to changes in the environment that have been only partially identified. In this Series paper, we critically discuss candidate triggers of islet autoimmunity and factors thought to promote progression from autoimmunity to overt type 1 diabetes. We revisit previously proposed hypotheses to explain the growth in the incidence of type 1 diabetes in light of current data. Finally, we suggest a unified model in which immune tolerance to β cells can be broken by several environmental exposures that induce generation of hybrid peptides acting as neoautoantigens.
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