Parenteral versus oral iron therapy for adults and children with chronic kidney disease

LO Emma, EM Hodson, I Nistor… - Cochrane Database …, 2019 - cochranelibrary.com
Cochrane Database of Systematic Reviews, 2019cochranelibrary.com
Background The anaemia seen in chronic kidney disease (CKD) may be exacerbated by
iron deficiency. Iron can be provided through different routes, with advantages and
drawbacks of each route. It remains unclear whether the potential harms and additional
costs of intravenous (IV) compared with oral iron are justified. This is an update of a review
first published in 2012. Objectives To determine the benefits and harms of IV iron
supplementation compared with oral iron for anaemia in adults and children with CKD …
Background
The anaemia seen in chronic kidney disease (CKD) may be exacerbated by iron deficiency. Iron can be provided through different routes, with advantages and drawbacks of each route. It remains unclear whether the potential harms and additional costs of intravenous (IV) compared with oral iron are justified. This is an update of a review first published in 2012.
Objectives
To determine the benefits and harms of IV iron supplementation compared with oral iron for anaemia in adults and children with CKD, including participants on dialysis, with kidney transplants and CKD not requiring dialysis.
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