The role of tubular iron accumulation in the remnant kidney.
BJ Nankivell, J Chen, RA Boadle… - Journal of the American …, 1994 - journals.lww.com
Iron has been implicated in the pathophysiology of several models of acute and chronic
renal disease. In this study, energy-dispersive x-ray spectrometry was used to quantify and
localize iron in rat remnant kidneys (RK) and normal kidneys (NK) and to determine its
pathophysiologic significance. Substantial iron accumulation occurred in proximal tubular
cell secondary lysosomes of RK (P< 0.001 versus NK) and reached a plateau at 8 wk after
partial nephrectomy. In NK, minor increases of iron also occurred with aging (P< 0.02) …
renal disease. In this study, energy-dispersive x-ray spectrometry was used to quantify and
localize iron in rat remnant kidneys (RK) and normal kidneys (NK) and to determine its
pathophysiologic significance. Substantial iron accumulation occurred in proximal tubular
cell secondary lysosomes of RK (P< 0.001 versus NK) and reached a plateau at 8 wk after
partial nephrectomy. In NK, minor increases of iron also occurred with aging (P< 0.02) …