[HTML][HTML] New strategy to control cell migration and metastasis regulated by CCN2/CTGF
DP Aguiar, GC de Farias, EB de Sousa… - Cancer cell …, 2014 - Springer
DP Aguiar, GC de Farias, EB de Sousa, J de Mattos Coelho-Aguiar, JC Lobo, PL Casado…
Cancer cell international, 2014•SpringerConnective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family
member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates
cell adhesion, aggregation and migration in a large variety of cell types, including vascular
endothelial cells, fibroblasts, epithelial cells, aortic smooth muscle and also pluripotent stem
cells. Others matricellular proteins are capable of interacting with CCN2/CTGF to mediate its
function. Cell migration is a key feature for tumor cell invasion and metastasis. CCN2/CTGF …
member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates
cell adhesion, aggregation and migration in a large variety of cell types, including vascular
endothelial cells, fibroblasts, epithelial cells, aortic smooth muscle and also pluripotent stem
cells. Others matricellular proteins are capable of interacting with CCN2/CTGF to mediate its
function. Cell migration is a key feature for tumor cell invasion and metastasis. CCN2/CTGF …
Abstract
Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epithelial cells, aortic smooth muscle and also pluripotent stem cells. Others matricellular proteins are capable of interacting with CCN2/CTGF to mediate its function. Cell migration is a key feature for tumor cell invasion and metastasis. CCN2/CTGF seems to be a prognostic marker for cancer. In addition, here we intend to discuss recent discoveries and a new strategy to develop therapies against CCN2/CTGF, in order to treat cancer metastasis.
Springer
